Protein Details: Glutamate receptor ionotropic; kainate 2

Protein ID

ICDB_Pro_0521

Protein Name

Glutamate receptor ionotropic; kainate 2

Gene Name

Grik2; Glur6

Organism

Rattus norvegicus (Rat)

Length

908 amino acids

AlphaFoldDB

AF-P42260-F1-model_v4.pdb

Function

Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel; gated by L-glutamate and the glutamatergic agonist kainic acid. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change; leading to the opening of the cation channel; and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state; characterized by the presence of bound agonist. Modulates cell surface expression of NETO2. In association with GRIK3; involved in presynaptic facilitation of glutamate release at hippocampal mossy fiber synapses (By similarity). Independent of its ionotropic glutamate receptor activity; acts as a thermoreceptor conferring sensitivity to cold temperatures (By similarity). Functions in dorsal root ganglion neurons (By similarity).

Sequence

MKIISPVLSNLVFSRSIKVLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFNDRRLPGKETMA

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

BINDING 516; /ligand="L-glutamate"; BINDING 518; /ligand="L-glutamate"; BINDING 523; /ligand="L-glutamate"; BINDING 689; /ligand="L-glutamate"

Disease

Location

Highest expression is found in the olfactory lobe; piriform cortex; dentate gyrus; hippocampus; granular cell layer of the cerebellum; and in caudate-putamen

DOI ID

10.1038/351745a0; 10.1016/0014-5793(92)80753-4; 10.1016/0896-6273(93)90336-p; 10.1073/pnas.90.2.755; 10.1016/s0021-9258(17)32623-6; 10.1074/jbc.m109453200; 10.1074/jbc.m608194200; 10.1038/nature05736; 10.1016/j.neuron.2008.12.014; 10.1016/j.celrep.2012.01.003; 10.1016/j.neuroscience.2014.08.009; 10.1016/j.neuron.2005.01.031; 10.1073/pnas.0409573102; 10.1038/nsmb1178; 10.1016/j.neuron.2011.05.038

RefSeq

NP_062182.1